Bruker Avance 300 console with a Bruker 300 UltraShieldTM magnet, equipped with a 5 mm BBO BB (31P-109Ag)-1H probe with z-gradients. Acquisition is performed using a CentOS workstation with Bruker TopSpin 2.1pl8 software. The instrument is currently running in Icon-NMR Routine mode with manual sample loading.